Summary of sugar excretion following oral administration by population | ||||
---|---|---|---|---|
USA (N=22) | Peru* (N=19) | Zambia† (N=73) | p Value | |
Post-rhamnose (ug/mL), median (range) | 50.10 (0.29 to 213.00) | 102.00 (2.66 to 301.00) | 34.50 (1.58 to 847.00) | 0.354‡ |
Fractional recovery rhamnose (%), median (range) | 0.38 (0.00 to 1.84) | 0.61 (0.02 to 6.32) | 0.07 (0.00 to 1.50) | 0<0.001‡ |
Post-lactulose (μg/mL), median (range) | 6.78 (0.29 to 31.90) | 47.60 (4.23 to 379.00) | 75.40 (0.67 to 873.00) | <0.001‡ |
Fractional recovery lactulose (%), median (range) | 0.01 (0.00 to 0.07) | 0.15 (0.01 to 0.69) | 0.03 (0.00 to 0.35) | <0.001‡ |
LR ratio, median (range) | 0.14 (0.06 to 1.00) | 0.75 (0.15 to 5.02) | 2.26 (0.08 to 14.48) | <0.001‡ |
Abnormal post LRR compared to the American 95th centile | 1 (5%) | 10 (53%) | 60 (82%) | <0.001§ |
*Fractional recovery was available in 18 of the 19 Peruvian participants.
†Fractional recovery was only available in 67 of the Zambian participants. Other post-dose sugar concentrations were available for 73 of the Zambian participants.
‡Kruskal-Wallis test.
§χ2 Test.